Expression of the cyclin kinase inhibitor, p27kip1, in developing and mature human kidney.

@article{Combs1998ExpressionOT,
  title={Expression of the cyclin kinase inhibitor, p27kip1, in developing and mature human kidney.},
  author={H. L. Combs and S. Shankland and S. Setzer and K. Hudkins and C. Alpers},
  journal={Kidney international},
  year={1998},
  volume={53 4},
  pages={
          892-6
        }
}
It has been shown that glomerular visceral epithelial cells (VEC) proliferate during glomerulogenesis, but differentiated VEC of the fetal kidney do not. It is also recognized that the proliferative capacity of the VEC in mature kidneys is very limited, and according to some investigators, may be completely absent. The basis for this remains unknown. Cell proliferation is controlled by cell cycle-related proteins, of which one class, the cyclin kinase inhibitors (CKI), cause cell cycle arrest… Expand
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Renal expression and activity of the germinal center kinase SK2.
A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression.
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References

SHOWING 1-10 OF 30 REFERENCES
Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulonephritis.
Proliferative activity of intrinsic cell populations in the normal human kidney.
Visceral glomerular epithelial cells can proliferate in vivo and synthesize platelet-derived growth factor B-chain.
Mesangial cell proliferation mediated by PDGF and bFGF is determined by levels of the cyclin kinase inhibitor p27Kip1.
Enhanced expression of "muscle-specific" actin in glomerulonephritis.
Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67.
Platelets mediate glomerular cell proliferation in immune complex nephritis induced by anti-mesangial cell antibodies in the rat.
...
1
2
3
...