Expression of the coxsackie and adenovirus receptor in human lung cancers

Abstract

The aim of this study is to elucidate the relation between expression of coxsackie and adenovirus receptor (CAR) and formation of lung cancer. We investigated the expression of CAR by immunohistochemistry, Western blot and real-time RT-PCR in 120 lung cancers. We found that CAR expression in tumor tissues was significantly higher than that in normal lung tissues. CAR expression had a correlation with the histological grade of lung squamous cell carcinoma; however, there was no relationship between the CAR expression and the other clinical pathological features. In vitro, silencing or overexpression of CAR could significantly inhibit or promote colony formation, cell adhesion, and invasion in A549 cells. Our findings demonstrated that CAR may play an essential role in the formation of lung cancer.

DOI: 10.1007/s13277-012-0342-2

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@article{Chen2012ExpressionOT, title={Expression of the coxsackie and adenovirus receptor in human lung cancers}, author={Zhaoli Chen and Qian Wang and Jingran Sun and Ankang Gu and Min Jin and Zhiqiang Shen and Zhigang Qiu and Jing-Feng Wang and Xinwei Wang and ZhongLi Zhan and Junwen Li}, journal={Tumor Biology}, year={2012}, volume={34}, pages={17-24} }