Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect.

@article{Chen2001ExpressionOT,
  title={Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect.},
  author={A C H Chen and Yukihikko Shirayama and Kyung Hwan Shin and Rachael Lee Neve and Ronald S Duman},
  journal={Biological psychiatry},
  year={2001},
  volume={49 9},
  pages={753-62}
}
BACKGROUND Recent studies have demonstrated that chronic antidepressant treatment increases the expression of the cyclic amp (cAMP) response element binding protein (CREB) in rat hippocampus. The study presented here was conducted to determine if CREB is a relevant target that produces an antidepressant-like effect. METHODS We employed the herpes simplex virus (HSV)-mediated gene transfer technique to overexpress CREB and determined its effect on the learned helplessness and forced swim tests… CONTINUE READING

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