Expression of the c-Met proto-oncogene and its possible involvement in liver invasion in adult T-cell leukemia.

@article{Imaizumi2003ExpressionOT,
  title={Expression of the c-Met proto-oncogene and its possible involvement in liver invasion in adult T-cell leukemia.},
  author={Yoshitaka Imaizumi and Hiroyuki Murota and Shigeru Kanda and Yoshitaka Hishikawa and Takehiko Koji and Takashi Taguchi and Yuetsu Tanaka and Yasuaki Yamada and Shuichi Ikeda and Tomoko Kohno and Kazuo Yamamoto and Naoki Mori and Masao Tomonaga and Toshifumi Matsuyama},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2003},
  volume={9 1},
  pages={181-7}
}
c-Met is a tyrosine kinase receptor for hepatocyte growth factor and suggested to be involved in oncogenesis ormetastatic phenotypes in many malignancies. Adult T-cell leukemia (ATL) is a neoplasia characterized by massive invasion of the leukemic cells into various organs. Recently, we have reported frequent hepatic involvement and the relationship between liver invasion and the poor prognosis in ATL. In the present study, we investigated the expression of c-Met in ATL cells and its relation… CONTINUE READING