Expression of the breast cancer resistance protein (Bcrp1/Abcg2) in tissues from pregnant mice: effects of pregnancy and correlations with nuclear receptors.

@article{Wang2006ExpressionOT,
  title={Expression of the breast cancer resistance protein (Bcrp1/Abcg2) in tissues from pregnant mice: effects of pregnancy and correlations with nuclear receptors.},
  author={Honggang Wang and Xiaohui Wu and Kelly L. Hudkins and Andrei Mikheev and Huixia Zhang and Anshul Gupta and Jashvant D. Unadkat and Qingcheng Mao},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2006},
  volume={291 6},
  pages={E1295-304}
}
The breast cancer resistance protein (BCRP) plays an important role in drug disposition, including limiting drug penetration across the placental barrier. Our goal was to investigate the effects of pregnancy on Bcrp1 expression in pregnant mice. We examined Bcrp1 expression in placenta, kidney, liver, and small intestine at various gestational ages. Bcrp1 protein levels peaked at gestation day (gd) 15 in placenta, at gd 10 and 15 in kidney, and at gd 15 in liver; however, Bcrp1 protein levels… CONTINUE READING
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Sex-dependent expression and activity of the ATP-binding E1303 EFFECTS OF PREGNANCY ON BCRP1 EXPRESSION IN PREGNANT MICE AJP-Endocrinol Metab

  • G Merino, AE van Herwaarden, E Wagenaar, JW Jonker, AH. Schinkel
  • Mol Pharmacol
  • 2006
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