Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions.

@article{Reid2004ExpressionOT,
  title={Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions.},
  author={Delyth M. Reid and Mar{\'i}a Montoya and Philip R. Taylor and Persephone Borrow and Siamon Gordon and Gordon D Brown and Simon Y. C. Wong},
  journal={Journal of leukocyte biology},
  year={2004},
  volume={76 1},
  pages={
          86-94
        }
}
Dectin-1 is a pathogen-recognition receptor on macrophages (MPhis), neutrophils, and dendritic cells (DCs). On MPhis and bone marrow-derived DCs, it has been shown to mediate the nonopsonic recognition of and response to soluble and particulate yeast beta-glucans. We have optimized the immunohistochemical detection of Dectin-1 and demonstrated its expression on neutrophils, subpopulations of MPhis in splenic red and white pulp, alveolar MPhis, Kupffer cells, and MPhis and DCs in the lamina… CONTINUE READING
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