Expression of the baculovirus p35 gene inhibits mammalian neural cell death.

@article{Rabizadeh1993ExpressionOT,
  title={Expression of the baculovirus p35 gene inhibits mammalian neural cell death.},
  author={Shahrooz Rabizadeh and Douglas J Lacount and Paul D. Friesen and Dale E. Bredesen},
  journal={Journal of neurochemistry},
  year={1993},
  volume={61 6},
  pages={2318-21}
}
Expression of the apoptosis suppressor gene p35, derived from the baculovirus Autographa californica nuclear polyhedrosis virus, markedly inhibited the cell death of stably transfected mammalian neural cells whether the cell death was induced by glucose withdrawal, calcium ionophore, or serum withdrawal. The p35 protein, which is required to block virus-induced apoptosis of cultured insect cells, is only the second gene product shown to block mammalian neural cell death, with Bcl-2 being the… CONTINUE READING