Expression of the antiapoptotic protein survivin in colon cancer.

@article{Hernandez2011ExpressionOT,
  title={Expression of the antiapoptotic protein survivin in colon cancer.},
  author={Jonathan M. Hernandez and Jeffrey M. Farma and Domenico Coppola and Ardeshir Hakam and William J. Fulp and Dung-Tsa Chen and Erin M. Siegel and Timothy Yeatman and David Shibata},
  journal={Clinical colorectal cancer},
  year={2011},
  volume={10 3},
  pages={
          188-93
        }
}

Figures from this paper

The transcriptional activity profile of inhibitor apoptosis protein encoding genes in colon cancer patients

The concentration of mRNA, encoding BIRC5 was elevated in samples obtained from more advanced colon cancer, suggesting BIRC 5 could be used as a complementary parameter for the diagnosis and prognosis of colon cancer.

Tumor Suppressor Protein p53 and Inhibitor of Apoptosis Proteins in Colorectal Cancer—A Promising Signaling Network for Therapeutic Interventions

The mechanistic and clinical importance of IAP regulation by p53 in CRC is highlighted and potential therapeutic strategies based on this interrelationship are described, including targeting their interrelationships by multimodal treatment options.

Baicalin induces apoptosis in SW480 cells through downregulation of the SP1 transcription factor

Baicalin inhibited sp1 expression and led to SW480 apoptosis, thus clarifying the effect of this traditional Chinese medicine compound in the treatment of colon cancer.

Expression of early growth response-1 in colorectal cancer and its relation to tumor cell proliferation and apoptosis.

Positive expression of Egr-1 was significantly associated with age, lymphovascular invasion, lymph node and distant metastasis, tumor stage and poor survival, and results indicate that EGr-1 may be associated with colorectal cancer progression via tumor cell proliferation.

Over-expression of survivin and VEGF in small-cell lung cancer may predict the poorer prognosis

The results indicated that survivin and VEGF were over-expressed in small-cell lung cancer, each of them may be an independent poor prognostic factor for SCLC patients.

ApoG2 inhibits the antiapoptotic protein, Mcl‑1, and induces mitochondria‑dependent apoptosis in human colorectal cancer cells.

ApoG2 inhibited the proliferation of the CRC cell lines through mitochondrial signaling pathway‑dependent apoptosis, which may be associated with the disruption of the function of the Mcl‑1 protein by ApoG2.

Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling

It is revealed that, depending on the cell context, Obatoclax suppresses WNT/β-catenin signaling in HCT 116 cells likely via inducing β-Catenin destabilization, or by downregulating LEF1 in DLD-1 cells.

Interplay between Endoplasmic Reticular Stress and Survivin in Colonic Epithelial Cells

It is provided evidence that ERS inhibition promoted apoptosis in LS174T cells and shortened the proliferation rate, which suggests a positive correlation between ERS and the inhibition of apoptosis.

Survivin is a guardian of the intestinal stem cell niche and its expression is regulated by TGF-β

It is demonstrated that Survivin is an essential guardian of embryonic gut development and adult gut homeostasis protecting the epithelium from cell death promoting the proliferation of intestinal stem and progenitor cells.
...

References

SHOWING 1-10 OF 58 REFERENCES

Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas.

A role for survivin in promoting aberrantly increased cell viability in gastric cancer is identified and a potential correlation between accumulated p53 and survivin expression in neoplasia is suggested.

Survivin expression in colorectal adenocarcinoma using tissue microarray.

Background: The additional prognostic information closely related to tumor cell biology is essential for the identification of patients with poor prognosis. Survivin, an identified inhibitor of

A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers.

  • M. MonzóR. Rosell A. Abad
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1999
It is concluded that survivin transcript is a defining diagnostic marker for NSCLC that may also yield prognostic information and, as an apoptosis inhibitor, be an important target in cancer therapy.

Cellular localisation of Survivin: impact on the prognosis in colorectal cancer

Results indicate that the analysis of the subcellular expression of survivin is a determining factor to define the prognostic value in patients with colorectal cancer.

Survivin, bcl-2 and matrix metalloproteinase-2 enhance progression of clear cell- and serous-type ovarian carcinomas.

The results suggest that the expression of apoptosis inhibiting factors and enhanced invasion ability affect progression of CA and SA, respectively.

Targeting survivin in cancer therapy: fulfilled promises and open questions.

Preclinical studies have demonstrated that down-regulation of survivin expression or function, accomplished by means of various strategies, reduced tumor growth potential, increased the apoptotic rate and sensitized tumor cells to chemotherapeutic drugs and radiation in different human tumor models.

Expression of survivin protein in human colorectal carcinogenesis

The expression of survivin is the essential event in the early stage of colorectal carcinogenesis and plays an important role in the transition sequence and it is not related to histological differentiation grade of coloresceptic carcinoma.

Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma.

Assessment of apoptotic index by in situ end-labeling revealed extremely low rates of apoptosis in most malignant melanomas, and data demonstrate that apoptosis inhibition by survivin may participate in the onset and progression of malign melanoma, and suggest that therapeutic targeting of Survivin may be beneficial in patients with recurrent or metastatic disease.

Oxaliplatin down-regulates survivin by p38 MAP kinase and proteasome in human colon cancer cells.

Evaluation of the immunohistochemical stain patterns of survivin, Bak and Bag-1 in colorectal cancers and comparison with polyps situated in the colon.

Cytoplasmic staining of Bag-1 can be considered an indicator of tumor progression, and decrease of supranuclear granular staining with Bak and Bcl-xl, and survivin expression, can be used as indicators of poor prognosis.
...