Expression of the antiapoptotic protein survivin in colon cancer.

@article{Hernandez2011ExpressionOT,
  title={Expression of the antiapoptotic protein survivin in colon cancer.},
  author={Jonathan M. Hernandez and Jeffrey M. Farma and Domenico Coppola and Ardeshir Hakam and William J. Fulp and Dung-Tsa Chen and Erin M. Siegel and Timothy Yeatman and David Shibata},
  journal={Clinical colorectal cancer},
  year={2011},
  volume={10 3},
  pages={
          188-93
        }
}
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The mechanistic and clinical importance of IAP regulation by p53 in CRC is highlighted and potential therapeutic strategies based on this interrelationship are described, including targeting their interrelationships by multimodal treatment options.

Baicalin induces apoptosis in SW480 cells through downregulation of the SP1 transcription factor

Baicalin inhibited sp1 expression and led to SW480 apoptosis, thus clarifying the effect of this traditional Chinese medicine compound in the treatment of colon cancer.

Expression of early growth response-1 in colorectal cancer and its relation to tumor cell proliferation and apoptosis.

Positive expression of Egr-1 was significantly associated with age, lymphovascular invasion, lymph node and distant metastasis, tumor stage and poor survival, and results indicate that EGr-1 may be associated with colorectal cancer progression via tumor cell proliferation.

Over-expression of survivin and VEGF in small-cell lung cancer may predict the poorer prognosis

The results indicated that survivin and VEGF were over-expressed in small-cell lung cancer, each of them may be an independent poor prognostic factor for SCLC patients.

ApoG2 inhibits the antiapoptotic protein, Mcl‑1, and induces mitochondria‑dependent apoptosis in human colorectal cancer cells.

ApoG2 inhibited the proliferation of the CRC cell lines through mitochondrial signaling pathway‑dependent apoptosis, which may be associated with the disruption of the function of the Mcl‑1 protein by ApoG2.

Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling

It is revealed that, depending on the cell context, Obatoclax suppresses WNT/β-catenin signaling in HCT 116 cells likely via inducing β-Catenin destabilization, or by downregulating LEF1 in DLD-1 cells.

Interplay between Endoplasmic Reticular Stress and Survivin in Colonic Epithelial Cells

It is provided evidence that ERS inhibition promoted apoptosis in LS174T cells and shortened the proliferation rate, which suggests a positive correlation between ERS and the inhibition of apoptosis.

Relationship of mismatch repair proteins and survivin in colon polyps and carcinomas.

Survivin is a guardian of the intestinal stem cell niche and its expression is regulated by TGF-β

It is demonstrated that Survivin is an essential guardian of embryonic gut development and adult gut homeostasis protecting the epithelium from cell death promoting the proliferation of intestinal stem and progenitor cells.
...

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