Expression of the antiapoptotic gene survivin in chronic myeloid leukemia.

@article{Badran2003ExpressionOT,
  title={Expression of the antiapoptotic gene survivin in chronic myeloid leukemia.},
  author={A. E. Badran and Akira Yoshida and Yuji Wano and Shin Imamura and Yasukazu Kawai and Hiroshi Tsutani and Manabu Inuzuka and Takanori Ueda},
  journal={Anticancer research},
  year={2003},
  volume={23 1B},
  pages={589-92}
}
Survivin, a unique member of the inhibitor of the apoptosis protein (IAPs) family, is over-expressed in many cancers but not in normal differentiated adult tissues. Using semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR), we investigated patterns of survivin gene expression in a group of 12 patients with chronic myeloid leukemia (CML) representing both chronic and blastic phases of the disease. All 6 patients in chronic phase CML were uniformly negative for the survivin… CONTINUE READING