Expression of the anthracycline-metabolizing enzyme carbonyl reductase 1 in hearts from donors with Down syndrome.

@article{Kalabus2010ExpressionOT,
  title={Expression of the anthracycline-metabolizing enzyme carbonyl reductase 1 in hearts from donors with Down syndrome.},
  author={James L. Kalabus and Carrie C Sanborn and Raqeeb G Jamil and Qiuying Cheng and Javier G Blanco},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2010},
  volume={38 12},
  pages={2096-9}
}
Cancer patients with Down syndrome (DS) are susceptible to developing anthracycline-related cardiotoxicity. The pathogenesis of anthracycline-related cardiotoxicity has been linked to the intracardiac synthesis of alcohol metabolites by carbonyl reductase 1 (CBR1). CBR1 is located in the DS critical region (21q22.12). The expression of CBR1 in hearts from individuals with DS has not been characterized. This study documented CBR1 expression in hearts from donors with DS (n = 4) and donors… CONTINUE READING

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Anthracycline - related cardiomyopathy in childhood cancer survivors and association with polymorphisms in the carbonyl reductase genes : a Children ’ s Oncology Group study

  • JG Blanco, C Sun, +7 authors S Bhatia
  • J Clin Oncol
  • 2010
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1 Excerpt

Anthracycline-related cardiomyopathy in childhood cancer survivors and assocation with polymorphisms in the carbonyl reductase genes: a Children’s Oncology Group study

  • JG Blanco, C Sun, +7 authors S Bhatia
  • J Clin Oncol
  • 2010
Highly Influential
1 Excerpt

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