Expression of the androgen receptor and 5α-reductase type 2 in the developing human fetal penis and urethra

  title={Expression of the androgen receptor and 5α-reductase type 2 in the developing human fetal penis and urethra},
  author={Kun Hong Kim and Wei Liu and Gerald R. Cunha and David W. Russell and Hongying Huang and Ellen Shapiro and Laurence S. Baskin},
  journal={Cell and Tissue Research},
Normal penile development is dependent on testosterone, its conversion via steroid 5α-reductase type 2 to dihydrotestosterone, and a functional androgen receptor (AR). The goal of this study was to investigate the distribution of AR and 5α-reductase type 2 in the developing human fetal external genitalia with special emphasis on urethra formation. Twenty fetal genital specimens from normal human males (12–20 weeks gestation) were sectioned serially and stained by avidin-biotinylated peroxidase… CONTINUE READING


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