Expression of the alpha chain of human Fc epsilon RI in transfected rat basophilic leukemia cells: functional activation after sensitization with human mite-specific IgE.

@article{Taudou1993ExpressionOT,
  title={Expression of the alpha chain of human Fc epsilon RI in transfected rat basophilic leukemia cells: functional activation after sensitization with human mite-specific IgE.},
  author={G. Taudou and Nadine Varin-Blank and H{\'e}l{\`e}ne Jouin and Françoise Marchand and Anne Weyer and Ulrich Blank},
  journal={International archives of allergy and immunology},
  year={1993},
  volume={100 4},
  pages={
          344-50
        }
}
The actual dilemma in studying the binding and triggering capacity of IgE from allergic patients is the lack of cultured basophils or mast cell analogs of human origin. Human IgE binds with exquisite species specificity to the high affinity IgE receptor (Fc epsilon RI) expressed on the surface of these cells. In rodents this receptor has been characterized as a tetrameric plasma membrane protein composed of an IgE-binding alpha chain, a beta chain and two disulfide-linked gamma chains. In order… CONTINUE READING
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