Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels.

@article{Platano2000ExpressionOT,
  title={Expression of the alpha(2)delta subunit interferes with prepulse facilitation in cardiac L-type calcium channels.},
  author={D Platano and Ning Qin and Francesca Noceti and Lutz Birnbaumer and Enrico Stefani and Riccardo Olcese},
  journal={Biophysical journal},
  year={2000},
  volume={78 6},
  pages={2959-72}
}
We investigated the role of the accessory alpha(2)delta subunit on the voltage-dependent facilitation of cardiac L-type Ca(2+) channels (alpha(1C)). alpha(1C) Channels were coexpressed in Xenopus oocytes with beta(3) and alpha(2)delta calcium channel subunits. In alpha(1C) + beta(3), the amplitude of the ionic current (measured during pulses to 10 mV) was in average approximately 1.9-fold larger after the application of a 200-ms prepulse to +80 mV. This phenomenon, commonly referred to as… CONTINUE READING

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