Expression of the activated p185erbB2 tyrosine kinase in human epithelial cells leads to MAP kinase activation but does not confer oncogenicity.

@article{Nowak1997ExpressionOT,
  title={Expression of the activated p185erbB2 tyrosine kinase in human epithelial cells leads to MAP kinase activation but does not confer oncogenicity.},
  author={Fabian Nowak and Alain G Jacquemin-Sablon and Josiane Pierre},
  journal={Experimental cell research},
  year={1997},
  volume={231 2},
  pages={251-9}
}
Amplification of the c-erbB2 gene and overexpression of p185erbB2 is found in approximately one-third of primary breast and ovarian cancers and also in some colon carcinomas. Moreover, a single point mutation in erbB2(V 664 E) confers transforming potential to erbB2 in NIH3T3 cells, even when expressed at low levels. To examine the transformation potential… CONTINUE READING