Expression of the RNA-binding protein IMP1 correlates with poor prognosis in ovarian carcinoma

@article{Kbel2007ExpressionOT,
  title={Expression of the RNA-binding protein IMP1 correlates with poor prognosis in ovarian carcinoma},
  author={Martin K{\"o}bel and Doreen Weidensdorfer and Claudia Reinke and Marcell Lederer and Wolfgang Daniel Schmitt and Kaixuan Zeng and Christoph Thomssen and Steffen Hauptmann and Stefan H{\"u}ttelmaier},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={7584-7589}
}
The IMP (IGFII mRNA-binding protein) family comprises a group of three RNA-binding proteins involved in the regulation of cytoplasmic mRNA-fate. Recent studies identified IMP proteins as oncofetal factors in various neoplasias, but knowledge of a potential role in ovarian carcinomas is still lacking. The immunohistochemical analysis of 107 ovarian carcinomas, 30 serous borderline tumors of the ovary and five normal ovaries revealed de novo synthesis of IMP1 in 69% of ovarian carcinomas… CONTINUE READING