Expression of the RNA-binding protein HuR and its clinical significance in human stage I and II lung adenocarcinoma.

@article{Lauriola2012ExpressionOT,
  title={Expression of the RNA-binding protein HuR and its clinical significance in human stage I and II lung adenocarcinoma.},
  author={Libero Lauriola and Pierluigi Granone and Sara Ramella and Paola Lanza and Franco Oreste Ranelletti},
  journal={Histology and histopathology},
  year={2012},
  volume={27 5},
  pages={617-26}
}
The ubiquitously expressed RNA-binding protein Hu antigen (HuR) participates in the post-transcriptional regulation of mRNAs bearing U- and AU-rich sequences. Expression of HuR is increased in cancers of the breast, colon, ovary and lung and cytoplasmic immunoreactivity for HuR was found to be closely related to poor outcomes in patients with these tumors. Since the regulation of HuR function is closely linked to its subcellular localization, we evaluated, by quantitative immunohistochemistry… CONTINUE READING

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