Expression of the PAX2 gene in human fetal kidney and Wilms' tumor.

@article{Eccles1992ExpressionOT,
  title={Expression of the PAX2 gene in human fetal kidney and Wilms' tumor.},
  author={M R Eccles and Lise J Wallis and Andrew E. Fidler and N. K. Spurr and Paul J Goodfellow and A. E. Reeve},
  journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research},
  year={1992},
  volume={3 5},
  pages={279-89}
}
We have examined the pattern of expression of the human PAX2 gene in Wilms' tumors and human fetal kidney by Northern blot and in situ hybridization. Human PAX2 encodes a paired box-containing protein and has a high degree of homology with mouse and Drosophila paired box genes. In situ hybridization analysis reveals that PAX2 is expressed in nephrogenic structures in fetal kidney and also in Wilms' tumors. This pattern of expression suggests that PAX2 may have a role in differentiation of… CONTINUE READING