Expression of the Opc protein correlates with invasion of epithelial and endothelial cells by Neisseria meningitidis.

@article{Virji1992ExpressionOT,
  title={Expression of the Opc protein correlates with invasion of epithelial and endothelial cells by Neisseria meningitidis.},
  author={Mumtaz Virji and Katherine M Makepeace and David J. P. Ferguson and Mark Achtman and J. F. Sarkari and E . Richard Moxon},
  journal={Molecular microbiology},
  year={1992},
  volume={6 19},
  pages={2785-95}
}
Whereas capsulate strains of Neisseria meningitidis are dependent on pili for adhesion to human endothelial and epithelial cells, strains which lacked assembled pili and were partially capsule-deficient adhered to and invaded human endothelial and epithelial cells if they expressed the Opc protein. Bacteria expressing low or undetectable levels of Opc protein failed to adhere to or invade eukaryotic cells. In addition, the presence of OpaAC751 protein on the surface of bacteria did not increase… CONTINUE READING