Expression of the Na+‐d‐Glucose Cotransporter SGLT1 in Neurons

@article{Poppe1997ExpressionOT,
  title={Expression of the Na+‐d‐Glucose Cotransporter SGLT1 in Neurons},
  author={Robert. Poppe and Ulrich Karbach and Stepan Gambaryan and Heinrich Wiesinger and Michael Lutzenburg and Matthias Kraemer and Otto W. Witte and Hermann Koepsell},
  journal={Journal of Neurochemistry},
  year={1997},
  volume={69}
}
Abstract: In brains of the rabbit, pig, and human, expression of the high‐affinity Na+‐d‐glucose cotransporter SGLT1 and of the protein RS1, which alters the activity of SGLT1, was demonstrated. In situ hybridization showed that SGLT1 and RS1 are transcribed in pyramidal cells of brain cortex and hippocampus and in Purkinje cells of cerebellum. In neurons of pig brain SGLT1 protein was demonstrated by western blotting with synaptosomal membranes and by immunohistochemistry, which showed SGLT1… 
Localization of the Na+-d-glucose cotransporter SGLT1 in the blood-brain barrier
TLDR
The data suggest that SGLT1 participates in transport of d-glucose across the blood-brain barrier and is upregulated after brain ischemia and reperfusion.
Regional distribution of SGLT activity in rat brain in vivo.
TLDR
The localization and the sensitivity of these neurons to anoxia prompt the speculation that SGLTs may play an essential role in glucose utilization under stress such as ischemia, and raises questions about the potential effects of SGLT inhibitors under development for the treatment of diabetes.
RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1.
TLDR
The data suggest that hRS1 protein exhibits glucose-dependent, short-term inhibition of hSGLT1 and hOCT2 by inhibiting the release of vesicles from the trans-Golgi network.
Induction of Ependymal, Glial, and Neuronal Transactivation by Intraventricular Administration of the SGLT1 Na+-D-Glucose Cotransporter Inhibitor Phlorizin
TLDR
Nonexcitable cells located throughout much of the central neuroaxis and discrete populations of neurons in the brain are genomically responsive to pharmacological inhibition of central SGLT1 function, and evidence for the functional responsiveness of these cell types to manipulation of energy-dependent glucose transport is shown.
Revised immunolocalization of the Na+-D-glucose cotransporter SGLT1 in rat organs with an improved antibody.
TLDR
An improved, more specific anti-rat S GLT1 antibody (rSGLT1-ab) is generated and may be used to identify novel sites of SGLT 1 localization and thus unravel additional physiological functions of this transporter in rat organs.
Localizations of Na+-d-glucose cotransporters SGLT1 and SGLT2 in human kidney and of SGLT1 in human small intestine, liver, lung, and heart
TLDR
The newly identified locations of hS GLT1 implicate several extra renal functions of this transporter, such as fluid absorption in the lung, energy supply to Clara cells, regulation of enteroendocrine cells secretion, and release of glucose from heart capillaries, which may be blocked by reversible SGLT1 inhibitors which are under development.
Mouse kidney expresses mRNA of four highly related sodium-glucose cotransporters: regulation by cadmium.
TLDR
Reabsorption of glucose in mouse kidney may involve four SGLTs, and the effect of cadmium on the second mouse kidney SGLT3 isoform, S GLT3-a, is investigated.
A Functional Role for Sodium-Dependent Glucose Transport across the Blood-Brain Barrier during Oxygen Glucose Deprivation
TLDR
Results show that both GLUT1 and S GLT play a role at the BBB in the blood-to-brain transport of glucose during ischemic conditions, and inhibition of SGLT during stroke has the potential to improve stroke outcome.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 61 REFERENCES
Regulation of Na+-coupled Glucose Transport in LLC-PK1 Cells
TLDR
The binding activity of SG-URBP is up-regulated after cyclic AMP elevation and protein kinase A activation, whereas protein dephosphorylation either in vivo or in vitro is associated with loss of binding activity.
Differentiation-dependent expression of the Na+/glucose cotransporter (SGLT1) in LLC-PK1 cells: role of protein kinase C activation and ongoing transcription.
TLDR
Changes in the mRNA level of SGLT1, a Na+/glucose cotransporter, is examined by the differentiation status of LLC-PK1 renal epithelial cells to find out whether protein kinase C activation appears to be involved in the dedifferentiation-induced decrease in S GLT1 mRNA.
Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes
TLDR
These studies indicated that the transport of AIB into brain cells was approximately 110 to 265 times greater than that across normal brain capillaries per unit mass of brain tissue, and that the BBB limits blood-to-brain cell transport of this amino acid.
The Human Brain GLUT1 Glucose Transporter: Ultrastructural Localization to the Blood—Brain Barrier Endothelia
  • E. Cornford, S. Hyman, B. Swartz
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1994
TLDR
It is suggested that the blood–brain barrier GLUT1 glucose transporter is up-regulated in seizures, and this elevated transporter activity is characterized by increasedGLUT1 transporters, particularly on the luminal capillary membranes.
Homology of the human intestinal Na+/glucose and Escherichia coli Na+/proline cotransporters.
TLDR
The cloning and sequencing of the human intestinal Na+/glucose cotransporter (SGLT1) is reported and its structure is compared with other cloned transporters and it is inferred that the mammalian Na+./glUCose and prokaryote Na+ /proline cOTransporters share a common ancestral gene.
Influence of Glucose Supply and Demand on Determination of Brain Glucose Content with Labeled Methylglucose
TLDR
Changes in brain glucose content induced by altered glucose utilization cause the brain glucose level and methylglucose distribution ratio to rise and fall in a direct relationship, in contrast to the inverse relationship between brain/plasma methyl glucose ratio.
Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals
  • I. Silver, M. Erecińska
  • Biology, Medicine
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
TLDR
It is concluded that continuous monitoring of glucose with glucose-specific microelectrodes provides a new and important insight into brain energy metabolism.
...
1
2
3
4
5
...