Expression of the Na(+)-K(+)-2Cl- cotransporter BSC2 in the nervous system.

  title={Expression of the Na(+)-K(+)-2Cl- cotransporter BSC2 in the nervous system.},
  author={Martin Plotkin and Miriam R. Kaplan and Linda N Peterson and Steve R Gullans and Steven C. Hebert and Eric Delpire},
  journal={The American journal of physiology},
  volume={272 1 Pt 1},
We used in situ hybridization and immunocytochemistry with polyclonal antibodies against the mouse bumetanide-sensitive Na(+)-K(+)-2Cl- cotransporter (mBSC2) to determine the location of this cotransporter in rat brain. Northern blots and in situ hybridization showed the presence of cotransporter mRNA in the brain, with an especially high level of expression in the choroid plexus (CP). Affinity-purified anti-BSC2 antibody identified proteins of 145-155 kDa on Western blot analysis and… CONTINUE READING
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