Expression of the Invasion Factor Laminin 2 in Colorectal Carcinomas Is Regulated by -Catenin


The migration-inducing 2 chain of laminin-5, one of the best known invasion markers, is strongly overexpressed in disseminating and infiltrating tumor cells at the invasive front of colorectal carcinomas. The same tumor cells show nuclear accumulation of the oncoprotein -catenin, which together with T-cell factor-DNA-binding proteins, functions as… (More)


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