Expression of the Huntington's disease transgene in neural stem cell cultures from R6/2 transgenic mice.

@article{ChuLaGraff2001ExpressionOT,
  title={Expression of the Huntington's disease transgene in neural stem cell cultures from R6/2 transgenic mice.},
  author={Q Chu-LaGraff and Xiaowei Kang and A. B. Messer},
  journal={Brain research bulletin},
  year={2001},
  volume={56 3-4},
  pages={307-12}
}
Huntington's disease (HD) is an inherited neurodegenerative disorder resulting in neuronal cell death in discrete brain regions due to an expanded CAG repeat of the huntingtin gene. The transgenic mouse model R6/2 expresses exon 1 of the human huntingtin gene with >150 CAG repeats, which produces mutant HD protein with an expanded poly-glutamine tract. We… CONTINUE READING