Expression of the Hantaan virus M genome segment by using a vaccinia virus recombinant.

@article{Pensiero1988ExpressionOT,
  title={Expression of the Hantaan virus M genome segment by using a vaccinia virus recombinant.},
  author={Michael N Pensiero and Georgia Jennings and Connie S. Schmaljohn and John Hay},
  journal={Journal of virology},
  year={1988},
  volume={62 3},
  pages={
          696-702
        }
}
A cDNA containing the complete open reading frame of the Hantaan virus (HTN) M genome segment has been cloned into vaccinia virus. This recombinant virus expresses two glycoproteins which are similar to the HTN structural glycoproteins, G1 and G2, in molecular weight, cleavage pattern, and cellular distribution. Both HTN and recombinant vaccinia virus glycoproteins are exclusively associated with the Golgi apparatus of the cell. Despite this intracellular restriction, mice inoculated with the… CONTINUE READING
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