Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis.

@article{Moransard2010ExpressionOT,
  title={Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis.},
  author={Martijn Moransard and Mandy Sawitzky and Adriano Fontana and Tobias Suter},
  journal={Glia},
  year={2010},
  volume={58 5},
  pages={559-71}
}
Hepatocyte growth factor (HGF) is a pleiotropic cytokine able to evoke a wide array of cellular responses including proliferation, migration, and survival through activation of its receptor c-met. Various types of leukocytes have been described to express c-met suggesting that HGF/c-met signaling may directly influence leukocyte responses in inflammation. We have investigated the HGF/c-met pathway in experimental autoimmune encephalomyelitis (EAE), a common mouse model of multiple sclerosis (MS… CONTINUE READING