Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues.

@article{Press1990ExpressionOT,
  title={Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues.},
  author={Michael F Press and Carlos Cordon-Cardo and Dennis J. Slamon},
  journal={Oncogene},
  year={1990},
  volume={5 7},
  pages={953-62}
}
The HER-2/neu proto-oncogene is homologous with, but distinct from, the epidermal growth factor receptor. Current evidence indicates that this gene is frequently amplified and/or overexpressed in some human breast and ovarian cancers and that these alterations may be clinically important; however, little is known about the expression pattern of the gene in normal tissues. Using immunohistochemistry and northern blot analyses to identify the HER-2/neu protein and transcript respectively, we have… CONTINUE READING

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