Expression of the Fe65 adapter protein in adult and developing mouse brain.

@article{Kesavapany2002ExpressionOT,
  title={Expression of the Fe65 adapter protein in adult and developing mouse brain.},
  author={Sashi Kesavapany and Steven J. Banner and K F Lau and Christopher E. Shaw and Christopher J Miller and Jonathan D Cooper and Declan M McLoughlin},
  journal={Neuroscience},
  year={2002},
  volume={115 3},
  pages={951-60}
}
Fe65 is a multimodular adaptor protein expressed mainly in the nervous system. Fe65 binds to the Alzheimer's disease amyloid precursor protein (APP) and the interaction is mediated via a phosphotyrosine binding domain in Fe65 and the carboxy-terminal cytoplasmic domain of APP. Fe65 modulates trafficking and processing of APP, including production of the beta-amyloid peptide that is believed to be central to the pathogenesis of Alzheimer's disease. Fe65 also facilitates translocation of a… CONTINUE READING
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