Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice.

@article{Kulwichit1998ExpressionOT,
  title={Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice.},
  author={Wanla Kulwichit and Robert H Edwards and Elisabeth Davenport and J F Baskar and Virginia Godfrey and Nancy Raab-Traub},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 20},
  pages={11963-8}
}
The latent membrane protein 1 (LMP1) of the Epstein-Barr virus has transforming properties in rodent fibroblasts and is expressed in most of the cancers associated with Epstein-Barr virus (EBV) infection including posttransplant lymphomas, Hodgkin's disease, nasopharyngeal carcinoma, and AIDS-related lymphomas. In this study, three lineages of LMP1 transgenic mice were established with LMP1 expressed under the control of the Ig heavy chain promoter and enhancer. Lymphoma developed in all three… CONTINUE READING
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Kulwichit et al

  • A. Strasser, A. W. Harris, M. L. Bath, Cory, S. Nature 348, 331–333. 11968 Microbiology
  • Proc. Natl. Acad. Sci. USA 95
  • 1998

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