Expression of the EGF receptor family members ErbB2, ErbB3, and ErbB4 in germinal zones of the developing brain and in neurosphere cultures containing CNS stem cells.

@article{Kornblum2000ExpressionOT,
  title={Expression of the EGF receptor family members ErbB2, ErbB3, and ErbB4 in germinal zones of the developing brain and in neurosphere cultures containing CNS stem cells.},
  author={Harley Ian Kornblum and Daniel S. Yanni and Mathew C. Easterday and Kim B. Seroogy},
  journal={Developmental neuroscience},
  year={2000},
  volume={22 1-2},
  pages={
          16-24
        }
}
The epidermal growth factor receptor family consists of four related tyrosine kinases: the epidermal growth factor receptor (EGF-R or ErbB), ErbB2, ErbB3, and ErbB4. These receptors are capable of extensive cross-activation upon the binding of their ligands - the EGF family of peptides for EGF-R and the neuregulins for ErbB3 and ErbB4. Since EGF-R is expressed by proliferating cells in the central nervous system (CNS), including multipotent CNS stem cells, we examined the expression of ErbB2… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 21 CITATIONS

Developmental control of cortico-cerebral astrogenesis.

  • The International journal of developmental biology
  • 2013
VIEW 1 EXCERPT
CITES BACKGROUND