Expression of the E6 and E7 genes of human papillomavirus (HPV16) extends the life span of human myoblasts.

Abstract

Primary human myoblasts (satellite cells), like other human cells, have a limited life span in vitro. Here we show that expression of the E6E7 early region from human papillomavirus type 16 can greatly extend the life span of both fetal and satellite cell-derived myoblasts and release them from dependence on the growth factors normally necessary for their… (More)

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Cite this paper

@article{Lochmller1999ExpressionOT, title={Expression of the E6 and E7 genes of human papillomavirus (HPV16) extends the life span of human myoblasts.}, author={Hans Lochm{\"u}ller and Thomas E Johns and Eric A Shoubridge}, journal={Experimental cell research}, year={1999}, volume={248 1}, pages={186-93} }