Expression of the CSF-1 gene in the blast cells of acute myeloblastic leukemia: association with reduced growth capacity.

@article{Wang1988ExpressionOT,
  title={Expression of the CSF-1 gene in the blast cells of acute myeloblastic leukemia: association with reduced growth capacity.},
  author={Chunjie Wang and C A Kelleher and Gui Yu Cheng and Jun Miyauchi and Gordon G. Wong and Steven C. Clark and Mark D Minden and E A Mcculloch},
  journal={Journal of cellular physiology},
  year={1988},
  volume={135 1},
  pages={133-8}
}
Myelopoietic growth factors are known to influence the growth in culture of malignant blast cells from human Acute Myeloblastic Leukemia (AML). We have used cDNA clones for the factor CSF-1 and its receptor fms to study DNA and RNA from the blasts of 25 AML patients. The CSF-1 gene was always in the germline configuration. CSF-1 mRNA was found in about half the blast populations. The cells were also studied for their growth properties in culture. A highly significant association was found… CONTINUE READING