Expression of the C-C chemokine receptor 7 mediates metastasis of breast cancer to the lymph nodes in mice.

@article{Cunningham2010ExpressionOT,
  title={Expression of the C-C chemokine receptor 7 mediates metastasis of breast cancer to the lymph nodes in mice.},
  author={Heather D. Cunningham and Laura A. Shannon and Psachal A. Calloway and Brian C. Fassold and Irene Dunwiddie and George A. Vielhauer and Ming Zhang and Charlotte M. Vines},
  journal={Translational oncology},
  year={2010},
  volume={3 6},
  pages={354-61}
}
C-C chemokine receptor 7 (CCR7) controls lymphocyte migration to secondary lymphoid organs. Although CCR7 has been implicated in targeting the metastasis of cancers to lymph nodes, the role of CCR7 in the metastasis of breast cancer, along with the molecular mechanisms that are controlled by CCR7 that target breast cancer metastasis to the lymph nodes, has yet to be defined. To explore the cellular and molecular mechanisms of breast cancer cell migration to the lymph nodes, we used the mouse… CONTINUE READING
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