Expression of telomerase subunits in normal and neoplastic prostate epithelial cells isolated by laser capture microdissection.

@article{Liu2001ExpressionOT,
  title={Expression of telomerase subunits in normal and neoplastic prostate epithelial cells isolated by laser capture microdissection.},
  author={Brian C. S. Liu and I LaRose and Lisa J Weinstein and Myung-ju Ahn and Michael H. Weinstein and Jerome P. Richie},
  journal={Cancer},
  year={2001},
  volume={92 7},
  pages={1943-8}
}
BACKGROUND Vertebrates have special structures at the ends of their chromosomes, known as telomeres, which may provide the chromosomes with stability and protect them from exonucleolytic degradation. The shortening of telomeric DNA with each cell division may lead to cell cycle arrest and/or apoptosis of a normal human somatic cell. Telomerase, an RNA-dependent DNA polymerase, elongates the 3'-ends of telomeric DNA. Thus, the presence of telomerase activity may reflect a cell's potential… CONTINUE READING