Expression of taxol resistance gene 1 correlates with gastric cancer patient clinical outcome and induces taxol resistance.

@article{Bai2010ExpressionOT,
  title={Expression of taxol resistance gene 1 correlates with gastric cancer patient clinical outcome and induces taxol resistance.},
  author={Zhi-Gang Bai and Xiang Qu and Wei Han and Xue-mei Ma and Xiao-mu Zhao and Zhong-Tao Zhang},
  journal={Molecular medicine reports},
  year={2010},
  volume={3 6},
  pages={1071-8}
}
In the present study, we investigated the effect of the taxol resistance gene 1 (TXR1) on taxol resistance in gastric cancer (GC). Immunohistochemistry was performed in order to assess the expression pattern of TXR1 in paraffin-embedded specimens of 107 GC patients who underwent radical D2 gastrectomy with long-term follow-up. In order to determine whether TXR1 expression plays a role in taxol resistance in GC cells, TXR1 was exogenously expressed or knocked down by siRNA in the absence and… CONTINUE READING
6 Extracted Citations
23 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 23 references

SN: Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes

  • lih C-J, W Wei, Cohen
  • Genes Dev
  • 2006
Highly Influential
3 Excerpts

Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by aBT737

  • Kutuk o
  • Cancer Res
  • 2008

A taxing problem

  • Hutchinson e
  • Nat Rev Cancer
  • 2006
1 Excerpt

Similar Papers

Loading similar papers…