Expression of target genes of nuclear factor E2-related factor 2 in the liver of dairy cows in the transition period and at different stages of lactation.

@article{Gessner2013ExpressionOT,
  title={Expression of target genes of nuclear factor E2-related factor 2 in the liver of dairy cows in the transition period and at different stages of lactation.},
  author={Denise K. Gessner and Gloria Schlegel and Janine Keller and Frieder J Schwarz and Robert Ringseis and Klaus Eder},
  journal={Journal of dairy science},
  year={2013},
  volume={96 2},
  pages={1038-43}
}
In the liver of dairy cows, the production of cytokines is enhanced during the periparturient phase, which in turn leads to inflammation and an impairment of hepatic function. Nuclear factor E2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that controls the transcription of genes encoding various antioxidative and cytoprotective proteins. In the present study, we investigated the hypothesis that Nrf2 is activated in the liver of dairy cows during the periparturient phase to… CONTINUE READING