Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa.

  title={Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa.},
  author={Roberto Gianani and Elke A. Jarboe and David O. Orlicky and Michael Frost and Julia Bobak and Rainer Lehner and Kenneth R. Shroyer},
  journal={Human pathology},
  volume={32 1},
The regulation of apoptotic cell death may have a profound effect on the pathogenesis and progression of colon cancer. Survivin, a member of the inhibitor of apoptosis gene family, has been detected in fetal tissue and in a variety of human malignancies. In the current study, we investigated survivin expression by an immunohistochemical approach in benign, hyperplastic, premalignant, and malignant lesions of the colon. Survivin was detected in all cases of normal colonic mucosa (20/20… CONTINUE READING
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