Expression of survivin correlates with apoptosis, proliferation, and angiogenesis during human colorectal tumorigenesis.

@article{Kawasaki2001ExpressionOS,
  title={Expression of survivin correlates with apoptosis, proliferation, and angiogenesis during human colorectal tumorigenesis.},
  author={Hirohide Kawasaki and Masao Toyoda and Hisashi Shinohara and Junji Okuda and Ichizo Watanabe and Tatsuyoshi Yamamoto and Kenichiro Tanaka and Toshiyuki Tenjo and Nobuhiko Tanigawa},
  journal={Cancer},
  year={2001},
  volume={91 11},
  pages={2026-32}
}
BACKGROUND To identify the role of survivin, a novel inhibitor of apoptosis (IAP) in colorectal tumorigenesis, the authors investigated tissue expression of survivin in human colorectal tumors including 43 hyperplastic polyps, 171 adenomas with low dysplasia, 42 adenomas with high dysplasia, and 60 carcinomas in adenoma, and examined whether the expression of survivin correlated with tumor cell apoptosis, proliferation, and angiogenesis, which is known to initiate the imbalance between cell… CONTINUE READING
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