Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals.

@article{An2009ExpressionOS,
  title={Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals.},
  author={Susun An and Seoyoung C Kim and Yong Huh and Tae Ryong Lee and H N Kim and Kui-Lea Park and Hee Chul Eun},
  journal={Contact dermatitis},
  year={2009},
  volume={60 4},
  pages={185-92}
}
BACKGROUND Evaluation of skin sensitization potential is an important part of the safety assessment of cosmetic ingredients and topical drugs. Recently, evaluation of changes in surface marker expression induced in dendritic cells (DC) or DC surrogate cell lines following exposure to chemicals represents one approach for in vitro test methods. OBJECTIVE The study aimed to test the change of expression patterns of surface markers on THP-1 cells by chemicals as a predictive in vitro method for… CONTINUE READING