Expression of surface antigens and its relation to parameters of malignancy in human malignant melanoma

@article{Brueggen2004ExpressionOS,
  title={Expression of surface antigens and its relation to parameters of malignancy in human malignant melanoma},
  author={Josef Brueggen and Egon Macher and Clemens Sorg},
  journal={Cancer Immunology, Immunotherapy},
  year={2004},
  volume={10},
  pages={121-127}
}
Human malignant melanoma cell lines were assayed for secretion of plasminogen activator (PA) and for growth in the nude mouse. It was observed that cell lines that were high producers of PA also grew in the nude mouse. In order to detect differences in membrane constituents of cells related to these parameters of malignancy, antisera were raised in non-human primates against the high producer (Mel A-375) and the non-producer cell of PA (SK-Mel 25). After extensive absorption the two antisera… CONTINUE READING

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