Expression of suppressors of cytokine signaling in diseased periodontal tissues: a stop signal for disease progression?

@article{Garlet2006ExpressionOS,
  title={Expression of suppressors of cytokine signaling in diseased periodontal tissues: a stop signal for disease progression?},
  author={Gustavo Pompermaier Garlet and Cristina Ribeiro de Barros Cardoso and Ana Paula Campanelli and Walter J{\'u}nior Martins and Jo{\~a}o S. Silva},
  journal={Journal of periodontal research},
  year={2006},
  volume={41 6},
  pages={580-4}
}
BACKGROUND AND OBJECTIVE Inflammatory cytokines are thought to trigger periodontal tissue destruction. In addition to being regulated by anti-inflammatory mediators, their activity is under the control of suppressors of cytokine signaling (SOCS), which down-regulate the signal transduction as part of an inhibitory feedback loop. We therefore investigated the expression of SOCS-1, -2 and -3, and the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-10, in different forms of human… CONTINUE READING

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