Expression of stem-cell factor and its receptor c-kit protein in normal testicular tissue and malignant germ-cell tumours

@article{Bokemeyer1996ExpressionOS,
  title={Expression of stem-cell factor and its receptor c-kit protein in normal testicular tissue and malignant germ-cell tumours},
  author={C Carsten Bokemeyer and Markus Antonius Kuczyk and T. Jeffrey Dunn and Juergen Serth and Kristin Hartmann and Jens Jonasson and Torsten Pietsch and Udo Jonas and Hans-Joachim Schmoll},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={1996},
  volume={122},
  pages={301-306}
}
The proto-oncogene c-kit and its ligand stemcell factor (SCF) may play an important role in the development of normal and malignant testicular tissue. This study investigates the presence of SCF and c-kit protein in 32 orchiectomy specimens of patients with testicular cancer, in 5 specimens of normal testicular tissue and in three established non-seminomatous germ-cell cancer cell lines (H12.1, H32, 577ML) by an immunohistochemical approach. Out of 9 testicular cancer specimens classified as… CONTINUE READING
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