Expression of stem cell factor and c-kit in human neuroblastoma. The Children's Cancer Group.

@article{Cohen1994ExpressionOS,
  title={Expression of stem cell factor and c-kit in human neuroblastoma. The Children's Cancer Group.},
  author={Perrin S Cohen and Jasmine Hoi-Ting Chan and M Lipkunskaya and June L. Biedler and Robert C. Seeger},
  journal={Blood},
  year={1994},
  volume={84 10},
  pages={3465-72}
}
During development, mice with mutations of stem cell factor (SCF) or its receptor c-kit exhibit defects in melanogenesis, as well as hematopoiesis and gonadogenesis. Because melanocytes derive from neural crest cells, the role of SCF and c-kit was investigated in the neural crest-derived childhood tumor neuroblastoma. Using reverse transcription-polymerase chain reaction analysis, simultaneous expression of steady-state mRNA for the SCF ligand and its receptor c-kit was found in 14 of 14 (100… CONTINUE READING

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