Expression of sphingomyelin synthase 1 gene in rat brain focal ischemia

@article{Dmitrieva2008ExpressionOS,
  title={Expression of sphingomyelin synthase 1 gene in rat brain focal ischemia},
  author={Veronika G. Dmitrieva and Elena V. Torshina and Vadim V. Yuzhakov and Oksana V. Povarova and Lyudmila V Dergunova},
  journal={Brain Research},
  year={2008},
  volume={1188},
  pages={222-227}
}
Metabolites of the sphingomyelin cycle are reported to play an important role in neuronal death after ischemia. To elucidate the involvement of the key enzyme of this cycle, sphingomyelin synthase (SMS), in the mechanism underlying cerebral ischemia, we, for the first time, investigated changes in the mRNA expression of the SMS1 gene in rats after focal cerebral ischemia. According to our histological analysis, the damaged area is localized only in the ipsilateral cortex. In the ischemic cortex… CONTINUE READING

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