Expression of somatostatin receptors in uveal melanomas.

@article{Ardjomand2003ExpressionOS,
  title={Expression of somatostatin receptors in uveal melanomas.},
  author={N. Ardjomand and G. Schaffler and H. Radner and Y. El-Shabrawi},
  journal={Investigative ophthalmology \& visual science},
  year={2003},
  volume={44 3},
  pages={
          980-7
        }
}
PURPOSE To investigate the distribution of somatostatin receptor (SSR) subtypes 2, 3, and 5 in uveal melanomas and their diagnostic and possible therapeutic value. METHODS SSRs were investigated in 25 paraffin-embedded eyes with uveal melanomas and in 6 normal eyes without any disease, by using polyclonal antiserum directed to SSR2A, -2B, -3, and -5. Antigen expression was evaluated by a semiquantitative method. The expression pattern of SSR was correlated with the patients' ad vitam… Expand
Somatostatin Receptors as Molecular Targets in Human Uveal Melanoma
TLDR
The expression of somatostatin receptor types-1, -2, -3, -4, -5 (SSTR-1–5) in human UM tissue samples and in O CM-1 and OCM-3 human UM cell lines suggests that they could serve as a potential molecular target for therapy of UM using modern powerful cytotoxic SST analogs targeting SSTR-2 and S STRs. Expand
Somatostatin receptor scintigraphy in patients with metastatic uveal melanoma
TLDR
Almost 50% of the uveal melanoma patients with extensive metastatic disease were positive for SSR, which was consistent with immunohistochemical staining for SSTR-2A, which suggested therapeutic approaches targeting SSTR might be beneficial in patients with metastatic uvea melanoma. Expand
Expression of the SST receptor 2 in uveal melanoma is not a prognostic marker
TLDR
It is concluded that SSTR2 is not widely expressed in UM and is not suited as prognostic marker or therapeutic target in UM, and was not associated with tumor-free survival and prognostic factors. Expand
[The incidence of somatostatin receptors in human neoplasms in the light of ex vivo-in vitro studies].
TLDR
This review presents the data, obtained by means of different in vitro techniques, on the incidence of five sstr subtypes in the different human tumors, deriving from endocrine glands, diffuse neuroendocrine cells as well as in neoplasms considered as non-endocrine. Expand
Somatostatin receptors and their interest in diagnostic pathology
TLDR
The role of the pathologist in typing the different sst present in a given sample is becoming more and more crucial, particularly in the field of neuroendocrine oncology, where sst typing may affect the clinical management of patients with sst-positive tumors. Expand
Expression of Somatostatin Receptors in Human Melanoma Cell Lines: Effect of Two Different Somatostatin Analogues, Octreotide and SOM230, on Cell Proliferation
TLDR
The results suggest that melanoma cell lines express SSTRs, and that novel SAs, combination therapy with SAs and their anti-angiogenic properties should be further investigated. Expand
Neuroendocrine aspects of cutaneous melanoma: focus on somatostatin receptors (SSTRs) expression and role of the pan-SSTR-agonist Pasireotide on cell proliferation
TLDR
Four cutaneous melanoma cell lines: A375, HMCB, COLO38 and M14 were used as in vitro models of CMM and the effects of SST analogs in relation to SSTR protein expression were evaluated, exploring the role of S ST pathway as a potential therapeutic target in human CMM. Expand
Somatostatin receptor scintigraphy with 111In-DOTA-lanreotide and 111In-DOTA-Tyr3-octreotide in patients with stage IV melanoma: in-vitro and in-vivo results
TLDR
The results demonstrate the visualization of metastatic melanoma in a high percentage of patients, probably due to binding of SST analogues to SST-Rs on tumour vessels or infiltrating immune cells. Expand
Prognostic assessment of choroidal melanoma based on interphase cytogenetics and pathological features.
TLDR
The results confirmed the work of previous studies that monosomy 3 is an important predictor of death in choroidal melanoma and showed that disomy 3 does not guarantee survival since a small group of tumours displaying disomy3 resulted in metastatic death. Expand
Somatostatin and chemokine CXCR4 receptor expression in pancreatic adenocarcinoma relative to pancreatic neuroendocrine tumours
Pancreatic adenocarcinoma (PAC) represents one of the most fatal types of cancer with an exceptionally poor prognosis, underscoring the need for improved diagnostic and treatment approaches. AnExpand
...
1
2
3
4
...

References

SHOWING 1-10 OF 37 REFERENCES
Distribution and Functional Significance of Somatostatin Receptors in Malignant Melanoma
TLDR
These studies clearly define melanoma as a neuroendocrine tumor and study the expression of SSTRs in melanoma to demonstrate a potential role for octreotide in the treatment of melanoma, which may open new avenues for tumor control. Expand
Expression of somatostatin receptor types 2, 3 and 5 in biopsies and surgical specimens of human lung tumours
TLDR
Octreoscan findings and sst expression were correlated in 22/25 cases, thus indicating that a cell membrane sst immunoreactivity in a biopsy reliably predicts the tumor–receptor profile before its resection. Expand
The current status of somatostatin receptors in malignant melanoma.
TLDR
It is concluded that melanomas contain somatostatin receptors and that this property might be used for imaging, tumor suppression with Octreotide, and/or as a target forOctreotide labelled with therapeutic agents such as immune complexes, chemotherapeutic agents or high energy radioisotopes. Expand
Immunohistochemical determination of five somatostatin receptors in meningioma reveals frequent overexpression of somatostatin receptor subtype sst2A.
  • S. Schulz, S. Pauli, +4 authors V. Höllt
  • Medicine, Biology
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2000
TLDR
The frequent overexpression of the sst2A receptor may explain the high tracer uptake often observed in meningioma patients during somatostatin receptor scintigraphy and this simple immunohistochemical method could prove useful in identifying those cases of recurrent disease that may possibly respond to therapy with sst 2-selective agonists. Expand
The diagnostic utility of somatostatin receptor scintigraphy in oncology
TLDR
The main value of SRS in oncology is in the staging and evaluation of gastroenteropancreatic tumours, paragangliomas, small-cell lung cancer and lymphomas, and initial results with targeted radionuclide therapy using radiolabelled octreotide have been reported. Expand
Immunocytochemical detection of somatostatin receptors sst1, sst2A, sst2B, and sst3 in paraffin-embedded breast cancer tissue using subtype-specific antibodies.
  • S. Schulz, S. Schulz, +7 authors V. Höllt
  • Biology, Medicine
  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 1998
TLDR
The immunocytochemical determination of somatostatin receptor status allows direct detection of receptor protein on the tumor cells and, hence, may provide more precise information than reverse transcription-PCR for predicting response to octreotide therapy in breast cancer. Expand
Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study.
TLDR
SSTR genes are widely expressed in normal human eye tissues, with genes for SSTR1 and SSTR2 being the most widely expressed. Expand
The role of somatostatin and its analogs in the diagnosis and treatment of tumors.
TLDR
Experimental studies show that chronic administration of somatostatin analogs causes growth inhibition of a number of (transplantable) tumors in animals, including chondrosarcomas, pancreatic, prostatic, breast, and pituitary cancers. Expand
Quantitative determination of sst2 gene expression in neuroblastoma tumor predicts patient outcome.
TLDR
It is proposed that sst2 expression represents a new prognostic marker for NB, which lies in its ability to detect patients at low risk, independently from other prognostic factor, including MYCN amplification. Expand
Detection of somatostatin receptor subtype 2 (SSTR2) in established tumors and tumor cell lines: Evidence for SSTR2 heterogeneity
TLDR
Somatostatin (SRIF) peptides with high SSTR2 affinity and antiproliferative properties were potent inhibitors of [125I]MK-678 binding to several tumor types, suggesting that they may exert antitumor effects via the Sstr2 receptor. Expand
...
1
2
3
4
...