Expression of somatostatin receptor subtypes 1-5 in pancreatic islets of normoglycaemic and diabetic NOD mice.

@article{Ludvigsen2005ExpressionOS,
  title={Expression of somatostatin receptor subtypes 1-5 in pancreatic islets of normoglycaemic and diabetic NOD mice.},
  author={Eva Ludvigsen and Mats Stridsberg and Eva Tiensuu Janson and Stellan Sandler},
  journal={European journal of endocrinology},
  year={2005},
  volume={153 3},
  pages={445-54}
}
OBJECTIVE Somatostatin acts on five specific receptors (sst1-5) to elicit different biological functions. The non-obese diabetic (NOD) mouse is an experimental model of type 1 diabetes. The aim of this study was to investigate whether the islet expression of sst1-5 is affected during the development of diabetes in NOD mice, with insulitis accompanied by spontaneous hyperglycaemia. METHODS By immunostaining for sst1-5 the expression and co-expression together with the four major islet hormones… CONTINUE READING

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