Expression of small proline rich proteins in neoplastic and inflammatory skin diseases.

@article{HellerMilev2000ExpressionOS,
  title={Expression of small proline rich proteins in neoplastic and inflammatory skin diseases.},
  author={Marina de Heller-Milev and Marcel Huber and Renato Panizzon and D. Hohl},
  journal={The British journal of dermatology},
  year={2000},
  volume={143 4},
  pages={
          733-40
        }
}
BACKGROUND The formation of the cornified cell envelope (CE) during the late stages of epidermal differentiation is essential for epidermal barrier function and protects the body against environmental attack and water loss. Formation of the CE involves the replacement of the plasma membrane by cross-linkage of precursor proteins such as involucrin, small proline rich proteins (SPRR) and loricrin. In normal epidermis, SPRR1 is restricted to appendages, SPRR2 is also expressed in interfollicular… CONTINUE READING
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