Expression of serotonin transporter protein in developing rat brain.

  title={Expression of serotonin transporter protein in developing rat brain.},
  author={Feng Chao Zhou and Youssef Sari and Jun-ke Zhang},
  journal={Brain research. Developmental brain research},
  volume={119 1},
Serotonin transporter (5-HTT), a transmembrane protein, has been shown in adult brain to be distributed not only on synaptic terminals but to a great extent on axons as well. Here we report the ontogeny of 5-HTT and its relationship with serotonin (5-HT) neurons using established 5-HTT and 5-HT antibodies. Both 5-HTT- and 5-HT-immunostaining (-im) appear in 5-HT neurons at embryonic day 12 (E12) in rostral raphe nuclei (RRN). Soon after appearing, 5-HTT-im is highly expressed on axons, similar… CONTINUE READING