Expression of selected gene for acquired drug resistance to EGFR-TKI in lung adenocarcinoma.

@article{Uramoto2011ExpressionOS,
  title={Expression of selected gene for acquired drug resistance to EGFR-TKI in lung adenocarcinoma.},
  author={Hidetaka Uramoto and Hidehiko Shimokawa and Takeshi Hanagiri and Michihiko Kuwano and Mayumi Ono},
  journal={Lung cancer},
  year={2011},
  volume={73 3},
  pages={
          361-5
        }
}
BACKGROUND Individualized treatment is an attractive challenge that may allow for more effective and safer treatment of human disease. Activating mutations in the epidermal growth factor receptor (EGFR) gene in lung adenocarcinoma are associated with a dramatic clinical response to EGFR-tyrosine kinase inhibitors (TKIs). However, patients often experience a relapse after treatment with EGFR-TKIs, even when the tumors are initially highly sensitive. However, the "whole picture" regarding… CONTINUE READING
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