Expression of scavenger receptor class B type I in gallbladder columnar epithelium

  title={Expression of scavenger receptor class B type I in gallbladder columnar epithelium},
  author={Magnus S C Johnson and Per-Arne Svensson and Jan Bor{\'e}n and H{\aa}kan Billig and Lena M. S. Carlsson and Bj{\"o}rn Carlsson},
  journal={Journal of Gastroenterology and Hepatology},
The lipid content of bile may be modified by the gallbladder epithelium. Recent studies indicate that cholesterol can be absorbed from bile and that this can be enhanced by apolipoprotein (apo) A‐I. SR‐BI is a multifunctional receptor capable of binding a wide array of native or modified lipoproteins, phospholipid or bile acid micelles. As apo A‐I is a ligand for scavenger receptor class B type I (SR‐BI) we have characterized the expression of this receptor in murine gallbladder. 
Cultured gallbladder epithelial cells synthesize apolipoproteins A-I and E.
Expression and regulation of scavenger receptor class B type I (SR-BI) in gall bladder epithelium
It is found that biliary cholesterol hypersecretion is associated with decreased gall bladder SR-BI expression in mice, and murineSR-BI is not essential in controlling gall bladder wall cholesterol content and gall stone formation during diet induced cholelithiasis.
Megalin and cubilin expression in gallbladder epithelium and regulation by bile acids Published, JLR Papers in Press, September 16, 2004. DOI 10.1194/jlr.M400235-JLR200
A physiological role for megalin and cubilin in the gallbladder is indicated and support for a role formegalin in gallstone pathogenesis is provided.
The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues.
Analysis of genetically manipulated strains of mice has established that SR-BI plays a key role in regulating lipoprotein metabolism and cholesterol transport to steroidogenic tissues and to the liver for biliary secretion, and it may be an attractive target for therapeutic intervention in cardiovascular and reproductive diseases.
Cultured gallbladder epithelial cells synthesize apolipoproteins A-I and E
Gallbladder epithelial cells (GBEC) are exposed to high and fluctuating concentrations of biliary cholesterol on their apical (AP) surface, and the mechanisms of this exposure are poorly understood.
The anionic peptide fraction is present on the gallbladder apical epithelium and favours biliary cholesterol absorption.
  • F. Liguori, N. Domingo, S. Ginanni Corradini
  • Medicine, Biology
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2007
Cholesterol uptake in adrenal and gonadal tissues: the SR-BI and 'selective' pathway connection.
The present review summarizes the functional importance of the selective pathway as a bulk cholesterol delivery system for steroidogenesis, and attempts to detail the expression, regulation and characteristics of SR-BI as it is deployed in steroidogenic systems as a means of achieving cholesterol balance.


Scavenger receptor BI and cholesterol trafficking.
These results and the similar pattern of SR-BI expression in humans emphasize that it is important to learn how this receptor influences lipoprotein metabolism and atherosclerosis in people.
Identification of a receptor mediating absorption of dietary cholesterol in the intestine.
It is shown that scavenger receptor class B type I is present in the small-intestine brush border membrane where it facilitates the uptake of dietary cholesterol from either bile salt micelles or phospholipid vesicles, and binds to high-density lipoprotein and apolipoprotein A-I, which lends further support to the conclusion that scavengers receptor BI catalyzes intestinal cholesterol uptake.
Scavenger Receptor Class B Type I as a Mediator of Cellular Cholesterol Efflux to Lipoproteins and Phospholipid Acceptors*
Studies that suggest that the presence of phospholipid on acceptor particles plays an important role in modulating interaction with the SR-BI are described, which may help to explain observations in the literature that document an increased risk of atherosclerosis in patients with depressed levels of HDL phospholIPid even in the face of normal HDL cholesterol levels.
Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat.
It is suggested that the scavenger receptor, class B, type I (SR-BI) mediates physiologically relevant uptake of cholesterol from HDL to nonplacental steroidogenic tissues in vivo.
Apolipoprotein A‐I in bile inhibits cholesterol crystallization and modifies transcellular lipid transfer through cultured human gall‐bladder epithelial cells
This study examined the cholesterol crystal growth‐inhibiting effect of biliary Apo A‐I at its physiological concentration, the modification of transcellular transfer ofbiliary lipids through cultured human gall‐bladder epithelial cells (GBEC) by Apolipoprotein A-I atIts physiological concentration and the binding and secretion of ApoA‐I by GBEC.
Expression of human scavenger receptor class B type I in cultured human monocyte-derived macrophages and atherosclerotic lesions.
This study clearly demonstrates that hSR-BI is expressed in the lipid-laden macrophages in human atherosclerotic lesions, suggesting that it is very important to know its function and regulation in hMphi to understand the biological utility of this molecule.
Identification of Scavenger Receptor SR-BI as a High Density Lipoprotein Receptor
It is shown that the class B scavenger receptor SR-BI is an HDL receptor, which mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway.
Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes*
The results demonstrate that CLA-1, a close structural homologue of SR-BI, is also functionally related toSR-BI and may play an important role as a “docking receptor” for HDL in connection with selective uptake of cholesterol esters and an additional role in recognition of damaged cells is suggested.
SR-BII, an Isoform of the Scavenger Receptor BI Containing an Alternate Cytoplasmic Tail, Mediates Lipid Transfer between High Density Lipoprotein and Cells*
These studies show that SR-BII, an HDL receptor isoform containing a distinctly different cytoplasmic tail, mediates selective lipid transfer between HDL and cells, but with a lower efficiency than the previously characterized variant.
Scavenger Receptor Class B Type I in the Rat Ovary: Possible Role in High Density Lipoprotein Cholesterol Uptake and in the Recognition of Apoptotic Granulosa Cells.
The data suggest that SR-BI mediates the recognition of apoptotic granulosa cells by the surrounding thecal cells and that it therefore may play a role in the remodeling of atretic follicles to secondary interstitial cells.