Expression of scavenger receptor‐AI promotes alternative activation of murine macrophages to limit hepatic inflammation and fibrosis

@inproceedings{Labonte2017ExpressionOS,
  title={Expression of scavenger receptor‐AI promotes alternative activation of murine macrophages to limit hepatic inflammation and fibrosis},
  author={Adam C. Labonte and Sun‐Sang J. Sung and Lucas T. Jennelle and Aditya Prakash Dandekar and Young S Hahn},
  booktitle={Hepatology},
  year={2017}
}
The liver maintains an immunologically tolerant environment as a result of continuous exposure to food and bacterial constituents from the digestive tract. Hepatotropic pathogens can take advantage of this niche and establish lifelong chronic infections causing hepatic fibrosis and hepatocellular carcinoma. Macrophages (Mϕ) play a critical role in regulation of immune responses to hepatic infection and regeneration of tissue. However, the factors crucial for Mϕ in limiting hepatic inflammation… CONTINUE READING
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