Expression of ring finger-deleted TRAF2 sensitizes metastatic melanoma cells to apoptosis via up-regulation of p38, TNFα and suppression of NF-κB activities

@article{Ivanov2001ExpressionOR,
  title={Expression of ring finger-deleted TRAF2 sensitizes metastatic melanoma cells to apoptosis via up-regulation of p38, TNFα and suppression of NF-κB activities},
  author={Vladimir N. Ivanov and \Oystein Fodstad and Ze'ev A Ronai},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={2243-2253}
}
Mechanisms underlying radiation and chemotherapy resistance, the hallmark of human melanoma, are not well understood. Here we demonstrate that expression levels of signal adaptor protein TRAF2 coincide with melanoma resistance to UV-irradiation. Altered TRAF2 signaling by a form of TRAF2, which lacks the ring finger domain (TRAF2ΔN), increases activities of p38 MAPK, ATF2, and the level of TNFα expression. Forced expression of TRAF2ΔN in HHMSX highly metastatic melanoma cells that lack Fas… CONTINUE READING

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References

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Showing 1-8 of 8 references

Phys

  • JG Peixoto, P. Andreo
  • Med. Biol., 45, 563 ± 575.
  • 2000
Highly Influential
6 Excerpts

Cell, 91, 243 ± 252

  • E Zandi, DM Rothwarf, M Delhase, M Hayakawa, M. Karin
  • Oncogene
  • 1997
Highly Influential
4 Excerpts

Curr

  • M Tyers, P. Jorgensen
  • Opin. Genet. Dev., in press.
  • 2000

Int

  • S Moretti, C Pinzi, +6 authors M. Herlyn
  • J. Cancer, 20, 160 ± 168.
  • 1999

Mol

  • P Tan, SY Fuchs, +4 authors ZQ. Pan
  • Cell, 3, 527 ± 533.
  • 1999

J

  • T Yuasa, S Ohno, JH Kehrl, JM. Kyriakis
  • Biol. Chem., 273, 22681 ± 22692.
  • 1998

Biochim

  • A Minden, M. Karin
  • Biophys. Acta., 1333, F85 ± F104.
  • 1997
2 Excerpts

Proc

  • HY Song, CH Regnier, CJ Kirschning, DV Goeddel, M. Rothe
  • Natl. Acad. Sci. USA, 94, 9792 ± 9796.
  • 1997

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